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In accordance, other authors have shown that induction of HO-1 in macrophages strongly promotes anti-inflammatory activity [54]

The pioneer work of Wilcken and Wilcken (1976) showed an abnormal increase in homocysteine after an oral methionine load in patients with coronary artery disease

This extended shelf life reduces waste and maintains consistency across multi-day protocols

However, bioavailability issues, lack of clinical standardization, and insufficient large-scale trials remain key obstacles that must be addressed before natural compounds can be integrated into mainstream AD therapy