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Practical Interpretation The mechanistic plausibility (NNMT NAD SIRT1/PGC-1 BMR & fat oxidation) is strong and consistent across preclinical models

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The adaptive signal encourages the organism to lower effort alternative strategies, e.g., alterations of dopamine and acetylcholine influx into the prefrontal cortex that occur with prolonged task performance is adaptive in the sense that it signals the need to abandon the ongoing behavior in such a way as to promote energy conservation