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Summary of different treatment options with their pros and cons Drug treatments Dopaminergic medications Dopaminergic medications are the typical treatment method for motor symptoms in PD, and L-DOPA, the most potent anti-parkinsonian drug currently available, remains the gold standard for PD therapy

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In particular, while activation of postsynaptic NMDA-type glutamate receptors leads to synaptic transmission of information, synaptic plasticity, and trophic effects on neurons, activation of extrasynaptic NMDA receptors inhibits these processes and can lead to neuronal damage and death (Hardingham & Bading, 2010)

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