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There are certain medical conditions where caution is needed

Some common symptoms include: Exhaustion, fatigue, weakness Pale or yellowed skin Heart palpitations Shortness of breath Nerve issues like tingling in the extremities Balance and coordination problems Anemia Mental health problems like depression and anxiety Cognitive issues like memory loss Vision problems If you suspect you may have a vitamin B12 deficiency, you should consult with a trusted healthcare professional to receive an accurate diagnosis and appropriate treatment intervention

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(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field