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MOTS-C does it directly, by suppressing TNF-alpha, IL-6, and IL-1 beta at the cellular level

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Keywords: Tendon, development, collagen, crosslinking, advanced glycation end products (AGEs), lysyl oxidase (LOX) Introduction Tendon is predominantly composed of collagen, which is hierarchically arranged in fibrils, fibers, and fascicles (Provenzano and Vanderby, 2006)