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Inflammation Reduction Eventually B12 decreases widespread inflammation, but initially oxidative stress and inflammatory flares may worsen temporarily from cleansing reactions

The animal data is striking

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In a second study, multiple procedures (median 3, range 2-18) of hydrodistension (80 cm H 2 O for 2 min) did not decrease bladder capacity in patients with IC/BPS (initial and final bladder capacities: 730 cc versus 750 cc