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Research in obese mice demonstrated that AOD-9604 increases beta-3 adrenergic receptor RNA expression, restoring levels comparable to those in lean mice

The dose ranges studied spanned from 0.25 mg to 54 mg, allowing for assessment of dose-response relationships in adverse effect profiles

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Infusion of obese Zucker rats as well as lean littermates with AICAR decreases plasma TAG and FA concentrations, as well as glycerol turnover (37), whereas mice lacking the AMPK-alpha2 subunit have been shown to have increased adiposity and weight gain (98, 131)