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Like OCPs, PCBs are highly lipophilic, eliciting concern for their persistent presence in the human body secondary to slow degradation even many years after cessation of use

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These hallmarks include sustained proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, avoiding immune destruction, tumor-promoting inflammation, genome instability and mutation, and deregulating cellular energetics

10.1016/j.jep.2016.06.056 30 DengG.CassilethB