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PIP 3 activates the kinase, PDPK1 (PIP 3 -dependent kinase 1) which then phosphorylates and activates the kinase, AKT2/PKB (often just written AKT/PKB or just AKT)

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FOXO6, as the most evolutionarily divergent member of this group, exhibits tissue-specific expression, particularly in liver, muscle, and neural tissues, and its effects on insulin signaling significantly differ from the other isoforms

Peters updated view on the potential of epigenome manipulation to restore aged cells to their youthful state [39:45]