The higher dose in the second half of the cycle is designed to reinforce the collagen synthesis, sirtuin activation, and anti-inflammatory pathways initiated in Phase 1
In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver
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Consequently, it is suggested that TB-500 may contribute to anti-inflammatory potential via these mechanisms