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For individuals who want visceral fat reduction without the systemic growth hormone effects, or who have contraindications to growth hormone elevation, AOD-9604 may be preferable

Dehydration risk is also higher in older adults, which amplifies the kidney safety advantage of tirzepatide (lower AKI reporting rate)

Further doseresponse and steady-state administration studies will be required to optimize the dosing schedule for future trials to evaluate therapeutic efficacy

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