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Importantly, this study identified novel candidate genes linked to insulin secretion and T2D risk: ERO1B (ER stress and protein folding), HNRNPA2B1 (an RNA-binding protein regulating insulin levels), and RHOBTB3 (involved in secretory protein trafficking), whose inhibition reduced intracellular insulin ( 4 Pancreasmicrobiota interactions The application of multi-omics approaches to the study of the pancreas provides the foundation for developing personalized therapeutic strategies tailored to the molecular and cellular profiles of individual patients (Mou et al., 2025)