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The increased volume and complexity of applications makes it more challenging to mitigate information gaps in advance of the final rule, particularly with regard to analysis and validation of information necessary to make determinations regarding whether technologies meet the add-on payment criteria

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The first is increased GSH neosynthesis as a result of processes that probably involve activation of cysteine and glutathione production at transcriptional and post-translational levels (Bick et al., 2009)