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Up to 80% of cirrhosis patients report poor sleep quality, as evidenced by Pittsburgh Sleep Quality Index (PSQI) scores exceeding 5 (ChildTurcottePugh [CTP] A: 16.9%, CTP B: 26.5%, and CTP C: 56.6%), and around 16 to 52% suffer from excessive daytime sleepiness (EDS), reflected by Epworth Sleepiness Scale (ESS) scores over 10 (CTP A: 17.6%, CTP B: 29.7%, CTP C: 52.8%) (31)

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DIV day in vitro Hippocampal slices which were biolistically transfected with the soluble red fluorescent protein Tomato were stimulated with 10 ng/ml HGF, 10 12 M Dihexa or vehicle for 48 hours