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Studies show that follicles in balding scalp areas have compromised blood supply compared to areas with normal hair density

A nasal spray is thus generally easier to administer than an intramuscular or subcutaneous injection

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Various emerging strategies for permeability regulation and BBB crossing including passive transcytosis, intranasal administration, ligands conjugation, membrane coating, stimuli-triggered BBB disruption, and other strategies to overcome BBB obstacle are highlighted