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Evidence that this particular group was less likely to have made a recent quit attempt suggests plain packaging could promote cessation attempts among smokers who have been less willing to try and quit, thus expediting achievement of the smokefree 2025 goal

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One possible explanation provided by gene expression data in 2024 suggests that smoking is significantly associated with the upregulation of the cytokine receptor-like factor-1 (CRLF1) gene, which translates to actin alpha 2 (ACTA2+) smooth muscle cells, particularly found in carotid plaques

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