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This innovative approach allows for the simultaneous exposure of human relevant cell types to whole smoke in a controlled environment, closely mimicking the actual conditions experienced by human lung tissue

Vidaki: The question is whether smoking also influences caffeine breakdown, or whether smokers happen to drink coffee more often than non-smokers. The connection with certain diseases, such as lung cancer, also needs further investigation

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A valid-PRS established based on such a process thus fulfils the definition of an instrumental variable mentioned above if it remains associated with the designated phenotype of interest