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The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

Notably, elevated concentrations of the dimeric macrocycles (above 100 nM) decreased the observed level of Met phosphorylation and this bell-shaped titration response was also observed with elevated concentrations of hHGF (above 5 nM)

Most protocols divide administration into loading and maintenance phases

This type of solution is available for injection use in subcutaneous, intramuscular, and intravenous areas