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Differently expressed GR and GPX induced by blue light which regulated GSSG-GSH cycle in glutathione metabolism Glutathione reductase (GR) is a key NADPH-dependent flavo-protein oxidoreductase which can catalyze the glutathione disulfide (GSSG) to reduced glutathione (GSH) and protect plant cells from oxidative damage induced by reactive oxygen species (ROS) burst [18]

5 Epigenetic-modulated inheritance and depression The estimated familial risk of depression is approximately 35%, compared to the 6570% hereditary rates for bipolar disorder and schizophrenia (189, 190)

Biological interpretation and validation would remain grounded in mechanistic studies, but the experimental search space could be narrowed

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