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Abbreviations AFC: Antral follicle count AFSCs: Amniotic fluid stem cells AMH: Anti-Mullerian hormone AMPK: AMP-activated protein kinase ANCA: Anti-neutrophil cytoplasmic antibody Apaf-1: Apoptotic protease activating factor-1 AP-1: Activator protein 1 ASC: Apoptosis-associated speck-like protein ATV: Atorvastatin ADSCs: Adipose-derived stem cells ADMSCs: Adipose-derived mesenchymal stromal cells ATP: Adenosine triphosphate Bax: Bcl-2 associated X protein BBR: Berberine Bcl-2: B-cell lymphoma 2 BID: BH3 interacting domain death agonist BMSCs: Bone marrow mesenchymal stem cells BUS: Buspirone bFGF: Basic fibroblast growth factor CAT: Catalase CNS: Central nervous system COX-2: Cyclooxygenase-2 CP: Cyclophosphamide CR: Curcumin DAMPs: Damage-associated molecular patterns DISC: Death-inducing signaling complex E2: Estradiol FDA: Food and Drug Administration Foxo3: Forkhead box O3 FSH: Follicle-stimulating hormone GnRH: Gonadotropin-releasing hormone GC: Granulosa cell GPx: Glutathione peroxidase GSDMD: Gasdermin D GSH: Glutathione hAECs: Human amniotic epithelial cells HaCat: Human adult low calcium temperature cells HO-1: Heme oxygenase-1 HRT: Hormone replacement therapy HUVEC: Human umbilical vein endothelial cell HUCMSCs: Human umbilical cord mesenchymal stem cells HGF: Hepatocyte growth factor IL-1: Interleukin-1 beta IL-6: Interleukin-6 IL-18: Interleukin-18 IGF-1: Insulin-like growth factor-1 IRAK: IL-1 receptor-associated kinase IRB: Irbesartan KEAP1: Kelch-like ECH-associated protein 1 LCZ696: Sacubitril/valsartan (drug combination) LVM: Levomilnacipran MAPK: Mitogen-activated protein kinase MDA: Malondialdehyde miRNA: MicroRNA MPO: Myeloperoxidase MSCs: Mesenchymal stem cells MTZ: MSCs mTOR: Mammalian target of rapamycin MyD88: Myeloid differentiation primary response 88 NAD: Nicotinamide adenine dinucleotide (oxidized form) NF-B: Nuclear factor kappa-light-chain-enhancer of activated B cells NLRP3: NOD-like receptor family pyrin domain-containing 3 inflammasome NO: Nitric oxide Nrf2: Nuclear factor erythroid 2-related factor 2 ONOO: Peroxynitrite PGC1-: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PI3K: Phosphatidylinositol 3-kinase PKB: Protein kinase B (also known as Akt) POF: Premature ovarian failure PPAR-: Peroxisome proliferator-activated receptor gamma PTEN: Phosphatase and tensin homolog RES: Resveratrol RGC32: Regulator of cell cycle ROS: Reactive oxygen species SIRT1: Silent information regulator-1 (sirtuin 1) SNRI: Serotonin and norepinephrine reuptake inhibitor SOD: Superoxide dismutase TIR: Toll-interleukin 1 receptor TIRAP: Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein TLR4: Toll-like receptor 4 TNF-: Tumor necrosis factor-alpha TRAF6: TNF receptor-associated factor 6 TRAM: Translocating chain-associated membrane protein TRIF: TIR-domain-containing adapter-inducing interferon- TGF-: Transforming growth factor VEGF-B: Vascular endothelial growth factor B Wnt: Wingless-related integration site (signaling pathway) References Aarsland D, Laake K, Larsen J, Janvin C (2002) Donepezil for cognitive impairment in Parkinsons disease: a randomised controlled study

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When the intestinal barrier becomes compromiseda condition known as leaky gut toxins, microbes, and food particles can escape into the bloodstream, triggering systemic inflammation, autoimmune reactions, and chronic disease

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