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GCL belongs to the class of proteins that are sensitive to oxidative stress, and its expression is mainly under the regulation of the Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), a transcription factor that regulates a wide array of antioxidant responsive element-driven genes in various cell types ( the novo GSH biosynthesis is glutathione synthase (GS)

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BioMed Pharmacother (2021) 137:111382