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[44] Knockout mice of any SOD enzyme are more sensitive to the lethal effects of superoxide-generating compounds, such as paraquat and diquat (herbicides)

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In a rat model of hyperthyroidism induced by levothyroxine sodium, total extract and large polar iridoid fractions of Scrophulariae Radix significantly decrease key enzymes involved in glycolysis and the tricarboxylic acid cycle under hypermetabolic conditions (103)

As a positive control for apoptosis, tamoxifen (50 M) was included (Mandlekar and Kong, 2001)