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The secondary metabolites (Table 8) and compounds (Table 9 and Figure 5) isolated from these plants also exhibited significant anti-HTN activity in preclinical studies

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However, we cannot exclude the possibility that the binding of the C19-A3 peptide to the gold directs its cleavage and presentation within the antigen presenting cells in vivo , favoring generation of immunogenic peptide fragments different from those produced in vitro from unconjugated C19-A3