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doi: 10.1016/S0140-6736(13)60687-X 51

doi: 10.1016/j.cmet.2016.01.006 229 ArnerPPetterssonAMitchellPJDunbarJDKharitonenkovARydnM

Although NSAIDs are effective in relieving the pain of chronic disorders, their long-term use is associated with a number of adverse effects , including GI bleeding, peptic ulcers, and renal and hepatic dysfunction