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We also found a positive effect of AOX supplementation on sperm morphology after the exclusion of studies carried out in patients with varicocele or treated with varicocele repair and AOX or placebo/no treatment [29, 31, 32, 50, 55], including a total of 1,413 infertile men (weighted MD 1.34% [95% CI: 0.13, 2.56]

Controlled human data is more limited, which is why it remains a research-use compound in most jurisdictions the gap between animal and human evidence is its most-cited limitation

(2002) Microglia promote glioma migration Acta Neuropathol., 103, 351-355 2

Cell culture studies demonstrate increased expression of synaptic proteins including PSD-95, synaptophysin, and synapsin following Dihexa treatment, confirming molecular mechanisms underlying the observed synaptogenic effects