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However, it is not only the airways, which represent the direct path of the smoke during active inhalation, that are affected

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Smokers during withdrawal demonstrated very small differences between both conditions: the BOLD responses were slightly increased during the presentation of the new GWLs in the parahippocampal gyrus/fusiform gyrus and occipital regions and slightly decreased, predominantly in the cuneus/precuneus as well as the middle/superior frontal gyrus (see Table 6, Fig 3)