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Studies of topical use have reported improvements in skin density, thickness, and appearance of fine lines over 12-week windows, with a well-documented safety profile at typical cosmetic concentrations (Borkow, Using Copper to Improve the Well-Being of the Skin, 2015)

4A), or by the ongoing administration of NMN alone during this period affecting folliculogenesis and ovulation rate independent of Dox treatment (as per Fig