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This comparison illustrates the gap between novel molecular mechanism discovery and validated clinical translation Dihexa represents frontier neuroscience with unresolved questions, while Cerebrolysin represents established but less mechanistically precise neurotrophic therapy

Lancet, 381(9860), 2939

Moreover, it is noteworthy that nanotechnology offers immense potential in preventing and alleviating PIPN via two main strategies: 1) enhancing the targeting accumulation and/or activity of Pt drugs at tumor tissues while decreasing the off-target effects and 2) specific delivery of antioxidant agents toward the peripheral nervous system

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