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This definition does not include any product that has been approved by the U.S

The HDL-Atherosclerosis Treatment Study (HATS), a three-year randomized controlled trial in 160 patients with documented CHD and low HDL concentrations, found that a combination of simvastatin and nicotinic acid (2-3 g/day) increased HDL concentrations, inhibited the progression of coronary artery stenosis (narrowing), and decreased the frequency of cardiovascular events, including myocardial infarction and stroke, compared to placebo (88)

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10 Coke (fuel) production: Workers at coking plants and coal-tar production plants where coal is refined to be used as a solid fuel may be exposed to coke oven emissions, and have an excess risk of dying from lung cancer and kidney cancer