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The transferrin receptor facilitates iron uptake from transferrin into cells, but the soluble transferrin receptor is detectable in serum following its cleavage from the membrane-bound receptor [74]

As a key regulator protector of antioxidants and cells, Nrf2 (nuclear factor (erythroid-derived 2)-like 2) is mainly activated in response to oxidative stress [63, 64]

Patients with significantly suppressed baseline IGF-1 (typically below 150 ng/mL in adults over 40) tend to see the most pronounced early changes because the distance from baseline to optimized is greatest

The Department of Medical Sciences, University of Turin has been supported by the MUR project Departments of Excellence 2018-2022 (project no