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This premise is based on the notion that subzero temperatures in supercooled storage can substantially slow down metabolism to mitigate the metabolic storage lesion and thus extend storage time

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44 Moreover, hyperglycemia-induced oxidative stress, AGEs, and chronic inflammation drive glomerular cell senescence through glycogen synthase kinase 3 (GSK3)-modulated nuclear factor erythroid 2-related factor 2 (Nrf2) signaling, impairing repair and worsening inflammation and fibrosis

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