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Heppner KM, Kirigiti M, Secher A, Paulsen SJ, Buckingham R, Pyke C, et al

Copper is an essential trace metal and a required cofactor for enzymes central to skin biology, including lysyl oxidase (which cross-links collagen and elastin) and superoxide dismutase (an antioxidant enzyme)

In clinical practice, it is valued for helping reduce oxidative stress, support detoxification pathways, and gradually improve overall skin clarity when used in structured IV or IM protocols

At the molecular level, this involves altered regulation of genes involved in pigmentation, particularly those encoding tyrosinase, a key enzyme in melanin biosynthesis