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LOXs are a group of dioxygenase enzymes that catalyze the oxygenation of arachidonic acid (AA) and polyunsaturated fatty acids (PUFAs) to produce hydroperoxyl derivatives [21]

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Endothelial cells line the inner layer of blood vessels that keep micro- and macro-vascular health by sensing pathogen/danger signals and secreting vasoactive (e.g., vasorelaxing and vasoconstricting) molecules and are essential for maintaining tissue homeostasis ( The prothrombotic phenotype and diffuse intravascular coagulation observed in COVID-19 also reflect ED ( Endothelial cell integrity is significantly affected by the cytokine storm induced by COVID-19