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Their influence on human fertility appears largely indirect , mediated by correction of metabolic disturbances that impair reproductive physiology

Dovato, which combines the integrase strand transfer inhibitor dolutegravir with the nucleoside reverse transcriptase inhibitor lamivudine, was approved to treat HIV-1 infection in adolescents 12 years and older, making it the first oral, two-drug, single-tablet regimen available for this patient population, according to ViiV

SEC45 and ARG50 have also been previously observed to be able to form interactions with known inhibitors [10, 22, 26]

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