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Additionally, there was variability between the included studies in the follow-up duration, which may cause heterogeneity in the results obtained

Currently Available Treatment Tirzepatide FDA-approved and commercially available as Mounjaro/Zepbound with established dosing protocols and post-market safety data Maximum Weight Loss Potential Retatrutide Phase 3 TRIUMPH-4 data showed 28.7% weight loss at 68 weeks (24.2% at 48 weeks in Phase 2), exceeding tirzepatide's results Non-Alcoholic Fatty Liver Disease Retatrutide Glucagon receptor agonism directly promotes hepatic fat oxidation, showing up to 82% liver fat reduction in trials Type 2 Diabetes Management Tirzepatide Proven HbA1c reduction with FDA approval specifically for glycemic control in type 2 diabetes Continue Your Research Get comparison updates We publish new head-to-head comparisons regularly

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