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The most widely encountered Causes of gynecomastia are: Hormonal PUBERTAL alterations Aging and the unavoidable decline of testosterone Chronic illness, like liver or renal illness Congenital defects Malignant testicular or adrenal neoplasms Intake of some prescribed or illicit drugs Some of the following drugs cause Gynecomastia: Anti-androgens (prostate or growth for cancer) Anabolic steroids and androgens Anti-anxiety drug Tricyclic antidepressants Cardiac drugs such as calcium channel blockers Anti-ulcer drugs such as cimetidine Alcohol, marijuana, heroin, and amphetamines also cause male breast enlargement

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In men, tobacco use has been associated with reduced fertility and an increased risk of impotence