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Therefore, it is vital that the genomic characterization of LCNS tumors is correlated with treatment responses and clinical outcomes to not only inform therapy selection, but also to advance discovery of targetable driver mutations and novel therapies

It has been shown that SIRT3 can suppress inflammation by decreasing the expression levels of NF - kB , high mobility group box 1 ( HMGB1 ), c - Jun , c - Fos , cyclooxygenase-2 ( COX2 ), TNF - , IL - 1 and IL - 6 [149]

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