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FIGURE 2 In contrast, with the administration of L-NAME, there was a moderate generalized irregularity in the diameter of blood vessels with moderate atrophy of the optic disc, faint presentation of the choroidal blood vessels appears immediately, and these lesions (Figure 2, IN, IIN) rapidly progress (Figure 3, AC

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The first large clinical trial was carried out David Rudd research group as an international, multicenter trial with three treatment schemes (200, 400, and 600 mg/day) [165]

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