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2016 Apr;74(4):248-58

Accordingly, the inhibition of the PI3K/AKT signaling pathway reduced lung inflammation by decreasing the expression of IL-4, IL-6, IL-8, TNF-, and IgE

Gastrointestinal effects such as nausea, vomiting, and diarrhea may arise, particularly at the start of treatment or after a dose increase

Others showed that increased levels of ROS dissociate replication accelerator-component from the replisome complex and slow down DNA synthesis as a safeguard for genome stability (Somyajit et al., 2017)