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coli , where a specific pair of ribosomal proteins were deuterated (S2-S5, S5-S8, and S3-S7) not only provided information on the distances between the centers of gravity of three protein pairs, but also showed that S5 and S8 were compact and S2 was extended (Engelman et al., 1975)

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At the molecular level, these observations are corroborated by the disrupted regulation of proteins that promote cell proliferation, such as cyclin D1, and those that form barrier-tight junctions, including zonula occludens-1, occludin, and claudins 1, 4, and 8 (Birder, 2019)