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[11] The preservation of female reproductive health is greatly aided by non-enzymatic dietary antioxidants, such as polyphenols (quercetin, baicalin, and resveratrol), carotenoids (-carotene, lutein, and lycopene), and low-molecular-weight antioxidants such as glutathione and uric acid

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When a person with Down syndrome has vitamin B12 and/or folate deficiency, the increase in the homocysteine level may not be great enough to overcome this starting low value of homocysteine