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doi: 10.1038/nature25158 215 BloomGS

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Overall, both surgical and medical treatments face limitations such as high recurrence rates or pronounced adverse effects, and there remains a lack of ideal long-term therapeutic options in clinical practice (9)

While the BBB serves as a barrier to restrict the passage of molecules, the integrity and function of the BBB can be compromised by disease states, disease-caused inflammation, and immune responses in the brain [1, 3, 9], or even systemic infection and inflammation [10] resulting in BBB disruption and greater BBB penetration [11]