10 , eaar8356 (2018)
We'll also send helpful GLP-1 guides to your inbox
Alzheimers disease (AD), the most common form of dementia worldwide 270,271 , is characterized at the molecular level by the accumulation of A plaques, tau neurofibrillary tangles (NFTs), declined NAD + levels, mitochondrial stress, and impaired mitophagy, occurring first in the medial temporal lobe and eventually spreading to temporal and parietal cortices, and cortex 112,242,243,270,271,272
Specifically, there must be executive coordination among levels of the following hormones and enzymes: Rise and fall in multiple forms of estrogen (endogenous estradiol, estrone, and estriol as well as environmental xenoestrogens and dietary phytoestrogens) and estrogen receptors Rise and fall in progesterone and progesterone receptors Rise and fall in follicle-stimulating and luteinizing hormones (FSH and LH) Cortisol and other stress hormones, which can affect overall hormone balance Aromatase, COMT (catechol-O-methyltransferase), and other key sex hormone-metabolizing enzymes