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For those prioritizing hair, specialized protocols with higher GHK-Cu doses or combination with hair-specific peptides may be more effective

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The pattern of side effects in long-term use shows that gastrointestinal symptoms are most prominent during the first 6 months, particularly during dose escalation

Consequently, Zubair et al did not recommend glutathione as a skin-lightening agent.14 In contrast, Weschawalit et al3 reported a statistically significant effect of glutathione as a skin-lightening agent, but this was limited to a group of participants aged older than 40 years who received GSH, a reduced form of glutathione, on the sun-exposed area of the right forearm.3 Arjinpathana et al1 used a Mexameter (Courage+Khazaka Electronic, Kln, Germany) to measure the melanin index as the main output parameter and found that glutathione was most effective on sun-exposed skin.1 In their systematic review, Dilokthornsakul et al15 likewise reported that glutathione might lighten skin tone in sun-exposed areas