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Functional enrichment (GO/KEGG) and Gene Set Enrichment Analysis (GSEA) revealed that GGCT knocking down significantly impacted pathways related to the cell cycle, oxidative stress, cell proliferation, and cell death in both cancers (Fig

By neutralizing free radicals, glutathione prevents your immune cells from being damaged while they are trying to protect you

Vashum KP, McEvoy M, Milton AH, McElduff P, Hure A, Byles J, et al

Further simulations showed that over a wide range of doxorubicin (050 M), the model can be used to suggest the specific concentration and exposure duration required to deplete cytosolic GSH by 70%, the threshold by which antioxidant defence is impaired, protein binding occurs, and cell death is possible