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Its the absence of large-scale human trials

Duzel, A., Vlainic, J., Antunovic, M., Malekinusic, D., Vrdoljak, B., Samara, M., Gojkovic, S., Krezic, I., Vidovic, T., Bilic, Z., Knezevic, M., Sever, M., Lojo, N., Kokot, A., Kolovrat, M., Drmic, D., Vukojevic, J., Kralj, T., Kasnik, K.,

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Small changes in the RMP or its basis can therefore induce large variations in the dual multipliers, resulting in dual oscillation and unstable pricing behavior in CG