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IGF-1 exerts its effects in the body by binding to a particular receptor, the IGF-1 receptor (IGF-1R)

Under hypoxic conditions, HIF-1 orchestrates a metabolic shift that favors lipid uptake, synthesis, and storage while modulating fatty acid oxidation in a context-dependent manner (111)

Fideles LS, Miranda JAL, Martins CS, Barbosa MLL, Pimenta HB, Pimentel PVS, Teixeira CS, Scafuri MAS, Faanha SO, Barreto JEF, Carvalho PMM, Scafuri AG, Arajo JL, Rocha JA, Vieira IGP, Ricardo NMPS, Campelo MS, Ribeiro MENP, Brito GAC, Cerqueira GS (2020) Role of Rutin in 5-fluorouracil-induced intestinal mucositis: prevention of histological damage and reduction of inflammation and oxidative stress