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Within the pancreatic islet microenvironment, pro-inflammatory macrophages and disrupted lipid homeostasis characterized by oxidized lipid deposition collectively drive the pathogenesis of both type 1 and type 2 diabetes (110)

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Lactate dehydrogenase (LDH) release and ATP levels confirmed these protective effects, showing a reduction in LDH release from 212.29% to 122.98% and restoring mitochondrial membrane potential to 94.62% at 50 M of the puerarin-loaded PLGA nanoparticles

At our practice, we frequently recommend vitamin B12 injections for patients who have difficulty adequately absorbing the vitamin through diet or oral supplements