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As the insulin receptor is expressed in all cell types and insulin signaling mediates diverse cellular functions, the detailed insulin function of each tissue has been extensively studied using tissue-specific Insr knockout mice 3,5 , in which Insr expression is almost completely disrupted in a specific cell type

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These findings indicated that the combination of (-)-Vestitol and Salviolone synergistically regulated more genes dysregulated in AD than either natural product alone did