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Despite advances in prevention and acute care, the overall CVDs burden continues to increase, underscoring the urgent need for more effective and comprehensive strategies to combat these diseases (World Health Organization, 2021

Principal Component Analysis (PCA) clearly separated their overall neurobehavioral profiles

33 , 34 After oral administration, absorption of glutathione is very poor mainly due to hydrolysis by intestinal and hepatic -glutamyltransferase as mentioned above, and for that reason, most therapeutic approaches using the oral route struggle to achieve results and the patients seek less safe treatments like intravenous treatment often under uncontrolled situations which may not be medically supervised, in some countries